What's more, he has demonstrated a particularly sharp eye for the 49ers. The CBS national writer went a profitable 29-16-1 in his last 46 NFL picks. 49ers picks and NFL predictions, you need to see what SportsLine expert Tom Fornelli has to say. Caesars Sportsbook lists the 49ers as two-point home favorites, while the over/under, or total number of points Vegas thinks will be scored, is 42.5 in the latest 49ers vs. The division-rivals are also participating in a rematch of last season's NFC Championship Game, with the Rams overcoming a 10-point deficit on the way to a win and an eventual Super Bowl title. The 49ers are 1-2 to begin the 2022 season, including an 11-10 loss to Denver in Week 3. The Rams are 2-1 overall and 1-0 on the road this season, with Los Angeles coming off a 20-12 win over Arizona last week. The Los Angeles Rams will hit the road to face the San Francisco 49ers on Monday Night Football.
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